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==Introdcution==
Amyloid infiltration occurs in all species - amaloid is an inert substance that becomes deposited under the endothelium and basement membranes of a variety of tissues, notably the renal glomeruli,
[[Pancreas - Anatomy & Physiology#Endocrine|Islets of Langerhans]] in the [[Pancreas - Anatomy & Physiology|pancreas]] and the [[Liver - Anatomy & Physiology|liver]] (between the sinusoidal reticulum and the hepatic cords).
==Causes==
May be a primary condition or appear secondary to some chronic tissue destructive process
May be a primary condition or appear secondary to some chronic tissue destructive process
*an infectious process elsewhere in the body
*an infectious process elsewhere in the body
*a result of sustained antigenic stimulation, eg repeated injections with an antigenic substance or production of excessive antibody by leukocytes
*a result of sustained antigenic stimulation, eg repeated injections with an antigenic substance or production of excessive antibody by leukocytes
==Gross Pathology==
*pale (greyish waxy appearance)
*pale (greyish waxy appearance)
*enlarged
*enlarged
*firm
*firm
*very prone to rupture
*very prone to rupture
====Microscopically====
====Microscopically====
*deposition of amyloid in the space of Disse
*deposition of amyloid in the space of Disse
==Arterial==
==Arterial==
Amyloid is an eosinophilic, homogenous, hyaline material. Due to its beta-pleated-sheet structure it is almost insoluble. Amyloid may be:
Amyloid is an eosinophilic, homogenous, hyaline material. Due to its beta-pleated-sheet structure it is almost insoluble. Amyloid may be:
*'''AA''': Serum amyloid A, alpha-2 globulin.
*'''AA''': Serum amyloid A, alpha-2 globulin.