Difference between revisions of "Pulmonary Infiltration with Eosinophilia"
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==History & Clincial signs== | ==History & Clincial signs== | ||
Eosinophillic lung diseases are seen in young and older dogs. It is rare in the Cat. | Eosinophillic lung diseases are seen in young and older dogs. It is rare in the Cat. | ||
| − | <br> Affected dogs usually present because of slowly progressive respiratory signs such as a cough, increased respiratory effort and exercise intolerance, wheezing and occasionally haemoptysis may be seen.The cough may be mild or severe, productive or nonproductive, and progressive or nonprogressive. Systemic signs are rarely present but may include | + | <br> Affected dogs usually present because of slowly progressive respiratory signs such as a cough, increased respiratory effort and exercise intolerance, wheezing and occasionally haemoptysis may be seen.The cough may be mild or severe, productive or nonproductive, and progressive or nonprogressive. Systemic signs are rarely present but may include anorexia and weight loss. There may be a history of a recurring cough which is unresponsive to antibiotics but often responsive to corticosteroid therapy. The clinical signs may be seasonal in appearance. |
<br> Severely affected animals may exhibit moderate to severe dyspnea and cyanosis at rest. | <br> Severely affected animals may exhibit moderate to severe dyspnea and cyanosis at rest. | ||
==Diagnosis== | ==Diagnosis== | ||
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Physical examination is largely normal. Thoracic auscultation may reveal crackles or expiratory wheezes. | Physical examination is largely normal. Thoracic auscultation may reveal crackles or expiratory wheezes. | ||
===Radiography=== | ===Radiography=== | ||
| − | The most | + | The most common radiographic finding is a diffuse ''Interstitial lung pattern'', a bronchial and/or alveolar pattern may also be visible. Eosinophilic Pulmonary Granulmatosis results in the formation of nodules, usually with indistinct borders. Consolidation of lung lobs and a hilar lymphadenopathy may also be seen. |
==Bronchoscopy== | ==Bronchoscopy== | ||
| − | Bronchoscopy may reveal increased amounts of mucous in the airways which may have a greenish | + | Bronchoscopy may reveal increased amounts of mucous in the airways which may have a greenish appearance. Tracheobronchial washes may show evidence of eosinophillic inflammation. Pulmonary specimens shouldbe carefully examined for the presence of infectious agents and for features od malignancy which may represent potential antigenic sources. |
[[Category:Allergic Respiratory Diseases]][[Category:To_Do_-_KatieB]] | [[Category:Allergic Respiratory Diseases]][[Category:To_Do_-_KatieB]] | ||
Revision as of 16:35, 16 November 2010
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This article is still under construction. |
Also known as : PIE - Eosinophillic Lung disease
Introduction
Pulmonary Infiltration with Eosinophilia (PIE) is a broad term describing an inflammatory lung disease in which the predominant infiltrating cell is the eosinophil. It is thought to be an immune mediated condition where the airway abnormalities are a consequence of a hypersensitivity reaction to an unidentified allergen such as microfilariae of heartworms, lungworms, chronic bacterial or fungal infections (eg, histoplasmosis, aspergillosis), viruses, external antigens, and unknown precipitating factors.
Eosinophillic pulmonary granulomatosis is a severe type of PIE seen in dogs and is characterzied by the development of nodules and hilar lymphadenopathy. It is most often associted with a hypersensitivity reaction to microfilarie in heartworm infection.
History & Clincial signs
Eosinophillic lung diseases are seen in young and older dogs. It is rare in the Cat.
Affected dogs usually present because of slowly progressive respiratory signs such as a cough, increased respiratory effort and exercise intolerance, wheezing and occasionally haemoptysis may be seen.The cough may be mild or severe, productive or nonproductive, and progressive or nonprogressive. Systemic signs are rarely present but may include anorexia and weight loss. There may be a history of a recurring cough which is unresponsive to antibiotics but often responsive to corticosteroid therapy. The clinical signs may be seasonal in appearance.
Severely affected animals may exhibit moderate to severe dyspnea and cyanosis at rest.
Diagnosis
Physical examination
Physical examination is largely normal. Thoracic auscultation may reveal crackles or expiratory wheezes.
Radiography
The most common radiographic finding is a diffuse Interstitial lung pattern, a bronchial and/or alveolar pattern may also be visible. Eosinophilic Pulmonary Granulmatosis results in the formation of nodules, usually with indistinct borders. Consolidation of lung lobs and a hilar lymphadenopathy may also be seen.
Bronchoscopy
Bronchoscopy may reveal increased amounts of mucous in the airways which may have a greenish appearance. Tracheobronchial washes may show evidence of eosinophillic inflammation. Pulmonary specimens shouldbe carefully examined for the presence of infectious agents and for features od malignancy which may represent potential antigenic sources.