Adaptive Immunity Flashcards

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ADAPTIVE IMMUNE SYSTEM
WIKIBLOOD FLASHCARDS


Actions and Tools of the Adaptive Immune System

Question Answer Article
Complete the sentence T cell receptors recognise antigen fragments on the cell surface. B cell receptors recognise whole antigen in the extracellular fluid Link to Answer Article
Dendritic cells and macrophages are types of which kind of cells?
  • Antigen presenting cells (APCs)
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What can CD3+ T cells differentiate into?
  • CD4+ Helper T cells
  • CD8+ Cytotoxic T cells
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What is the main function of T helper I cells?
  • Enhancing the macrophage response
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What is the main function of T helper II cells?
  • Enhancing the B cell antibody production
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Name 3 types of antigen binding molecules
  • Immunolglobulins
  • T cell receptors (TCRs)
  • Natural Killer cells (NK cells)
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Adaptive Immunity to Viruses

Question Answer Article
Which humoral factors are used against viruses in the adaptive response?
  • Production of neutralising antibody
  • Antibody-dependent cell mediated cytotoxicity (ADCC)
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What is the cell mediated adaptive response against viruses?
  • CD8+ T-cell mediated killing of virus infected cells
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How are viral infected cells killed by apoptosis?
  • Perforin and granzymes released to activate the caspase cascade
  • Fas-ligand triggers the Fas-mediated apoptosis pathway
  • Cytotoxic cytokines act on TNF receptors to induce programmed cell death
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Adaptive Immunity to Bacteria

Question Answer Article
What is the humoral response to bacterial infection?
  • Complement activation of the classical pathway
  • Production of IgM and IgG
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What is the cell-mediated response to bacterial infection?
  • Help for macrophages
  • Production of IgG
  • T helper type I cell help
Link to Answer Article
What is the response to an extracellular bacterial infection?
  • Complement and phagocytosis
  • Production of IgM
  • T helper type II and B cell production
  • Class switching of IgM to IgG
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What is the response to a vesicular bacterial infection?
  • IL-12 released from an infected macrophage
  • T helper type I cells stimulated
  • IFN-γ released triggering the macrophages to destroy the bacteria
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Adaptive Immunity to Parasites

Question Answer Article
What is the humoral response to a parasitic infection?
  • Production of IgE
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