Permethrin Toxicity



Introduction

Permethrin is the active ingredient of many 'spot-on' paraciticides used in the control of fleas and ticks in dogs [1].

Signalment

Permethrin poisoning in most commonly seen in cats who have inadvertently been administered spot-on products intended for use in dogs, or who have had contact with dogs following application of the preparations [2].

Diagnosis

Clinical Signs

Laboratory Tests

Pathology

The spot-on canine preparations are often quite concentrated.[2]. Cats lack the enzyme glucuronidase transferase [3] and is therefore unable to utilise the metabolic pathway that dogs and other animals use to break down permethrin into glucuronides and sulphates.

Treatment

Prognosis

References

  1. Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London, Journal of Feline Medicine and Surgery(2007)9,335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010
  2. 2.0 2.1 BSAVA Manual of Canine and Feline Emergency and Critical Care, Chapter 19, Second Edition, 2007
  3. Whittem 1995 Pyrethrin and pyrethroid insecticide intoxication in cats.Compendium of Continuing Education for the Veterinary Practitioner 17 489-492, referenced in Journal of Feline Medicine and Surgery(2007)9,335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010