Adaptive Immunity Flashcards

Actions and Tools of the Adaptive Immune System

Question	Answer		Article
Complete the sentence: T cell receptors recognise ??? fragments on the cell surface. B cell receptors recognise ??? in the ??? fluid.	antigen whole antigen extracellular		Link to Article
Dendritic cells and macrophages are types of which kind of cells?	Antigen presenting cells (APCs)		Link to Article
What can CD3+ T cells differentiate into?	CD4+ Helper T cells CD8+ Cytotoxic T cells		Link to Article
What is the main function of T helper I (TH1) cells?	Enhancing the macrophage response		Link to Article
What is the main function of T helper II (TH2) cells?	Enhancing the B cell antibody production		Link to Article
Name 3 types of antigen binding molecules	Immunolglobulins T cell receptors (TCRs) Natural Killer cells (NK cells)		Link to Article

Adaptive Immunity to Viruses

Question	Answer		Article
Which humoral factors are used against viruses in the adaptive response?	Production of neutralising antibody Antibody-dependent cell mediated cytotoxicity (ADCC)		Link to Article
What is the cell mediated adaptive response against viruses?	CD8+ T-cell mediated killing of virus infected cells		Link to Article
How are viral infected cells killed by apoptosis?	Perforin and granzymes released to activate the caspase cascade Fas-ligand triggers the Fas-mediated apoptosis pathway Cytotoxic cytokines act on TNF receptors to induce programmed cell death		Link to Article

Adaptive Immunity to Bacteria

Question	Answer		Article
What is the humoral response to bacterial infection?	Complement activation of the classical pathway Production of IgM and IgG		Link to Article
What is the cell-mediated response to bacterial infection?	Help for macrophages Production of IgG T helper type I cell help		Link to Article
What is the response to an extracellular bacterial infection?	Complement and phagocytosis Production of IgM T helper type II and B cell production Class switching of IgM to IgG		Link to Article
What is the response to a vesicular bacterial infection?	IL-12 released from an infected macrophage T helper type I cells stimulated IFN-γ released triggering the macrophages to destroy the bacteria		Link to Article

Adaptive Immunity to Parasites

Question	Answer		Article
What is the humoral response to a parasitic worm (helminth) infection?	Production of IgE		Link to Article

Originally funded by the RVC Jim Bee Award 2007