Transgenic Animals - Anatomy & Physiology

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• Many mouse transgenics have been created to serve as models for human genetic diseases.
• Less successful in other species, but goats have been created that secrete human factor VIII in their milk.
  • Cheap treatment for bleeding disorders with little risk of disease transfer.
• Area of much future development.
• Injection of specific gene constructs into the newly fertilized oocyte, so that they become part of the dividing cell. Thus they are encorporated and expressed in the individual.
• Constructs may be from the same or different species as the oocyte.