Immunoglobulins Flashcards

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IMMUNOGLOBULINS
WIKIBLOOD FLASHCARDS


Immunoglobulins Structure and Function

Question Answer Article
What are immunoglobulins also known as?
  • Antibodies
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How many domains does the heavy chain have?
  • 1 variable domain
  • 3 or 4 constant domains
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How many domains does the light chain have?
  • 1 variable domain
  • 1 constant domain
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What are hypervariable domains?
  • Folded pockets of the variable domain into which antibody can bind
  • Different antibodies have different amino acid sequences within the three variable domains
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What does Fab stand for and from which chain is it generated?
  • Fragment associated with antigen binding
  • Light chain
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What does Fc stand for and from which chain is it generated?
  • Constant fragment
  • Heavy chain
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What does the Fc fragment do?
  • Mediates phagocytosis
  • Triggers inflammation
  • Targets Ig to certain tissues
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What are the four major effects of antibodies?
  • Blockage and agglutination
  • Promotion of phagocytosis
  • Degranulation of mast cells/eosinophils
  • Complement Fixation
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Classes of Immunoglobulin

Question Answer Article
How do the five classes of immunoglobulins vary from each other?
  • They each have a different composition to their heavy chains
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IgA is specially adapted for function at which type of surface?
  • Mucosal surfaces
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True or False: IgA is a monomer
  • False
  • IgA is a dimer
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What are the functions of IgA?
  • Prevents agents from adhering to the epithelial surfaces as it binds to foreign antigen
  • Resists proteolytic digestion so can function in the gut
  • Does not activate the complement system so helps to preserve mucosal integrity
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In which species has IgD been identified?
  • Ruminants
  • Pigs
  • Dogs
  • Rodents
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What is the main function of IgD?
  • Helps B cell development
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True or False: IgE is not a soluble antibody?
  • True
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What are the functions of IgE?
  • Triggers acute inflammation by causing degranulation
  • Involved in type I hypersensitivity reactions
  • Involved in producing immunity to parasitic worms and nematode parasites
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True or False: IgG is the smallest antibody and can easily leave the plasma and enter tissue?
  • True
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Where is IgG produced?
  • Bone marrow
  • Spleen
  • Lymph nodes
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What is the function of IgG?
  • Activates the classical pathway of the complement cascade
  • Can act as targets for macrophages, eosinophils and neutrophils
  • Causes agglutination and opsonisation of bacteria
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Immunoglobulins Variation

Question Answer Article
What are immunoglobulins also known as?
  • Antibodies
Link to Answer Article



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