Mucoid Degeneration

Introduction

Mucoid degeneration is also known as mucinous or myomatous degeneration.
Mucoid degeneration involves changes in epithelial tissue or the extracellular matrix/ ground substance.
An extracellular phenomenon of some specific cells.
- Tend to show a bluish tinge in H&E stained sections.

The specific cells involved in mucoid degeneration in the eptihelium are:
- The goblet cells of wet mucous membranes.
- The mucous glands themselves.
This is not really a degeneration, but an increased production of mucin.
- It is a beneficial reaction; the product
  - Is important as a lubricant.
  - Soothes inflamed surfaces.
  - Traps and dilutes harmful agents.
  - Carries specific antibodies against infectious agents.
  - Provides a means for removal of infectious agents.

Here, the mucin forms part of the ground substance between the fibroblasts that produce it.
A disturbance in the metabolism of the fibroblasts under some circumstances,means the ground substance takes on a bluish hue in H&E sections.
Mucoid degeneration in the heart valves of middle-aged and older dogs is a common example.
- Causes endocardiosis.
  - A condition specific to the dog.