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Injection Site Reaction

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  • May be caused by subcutaneous injections
  • Granulomatous nodules form with central necrotic and foreign material
  • Macrophages and multinucleated giant cells around the centre
  • Surrounded by granulation tissue, perivascular lymphocytes that may form lymphoid follicles, eosinophils
  • Cats may develop fibrosarcomas secondary to vaccination
  • Dogs, especially poodles, may develop lymphoplasmacytic panniculitis and perivasculitis, vasculitis and follicular atrophy secondary to killed rabies vaccine
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