Equine Motor Neuron Disease

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Generalised LMN disorder
Degeneration of Ventral horn motor neuron
Chromatolysis
Neurofilament accumulation
Gliosis
Wallerian degeneration
Denervation changes in muscle
Weight Loss
Muscle atrophy
Generalised Weakness
Short strided gait + narrow based stance
Trembling
Sweating and fasiculations
Increased recumbency
Elevated CK
CSF protein
Denervation of EMG
May progress to constant recumbency (destroy), stabilise or improve