Chicken Anaemia Virus Disease Flashcards

Question	Answer		Article
What is Chicken Anaemia Virus Disease also commonly known as?	Chicken anaemia Chicken infectious anaemia Blue wing disease		Link to Article
Which virus causes Chicken Anaemia Virus Disease and what are it's properties?	Chicken anaemia virus (CAV): Non-enveloped icosahedral single stranded DNA (ssDNA) virus 23-25 nm diameter Small circular genome of negative sense Very hardy and resistant to high temperatures, acidic pH (pH3), chloroform and commercial disinfectants. Morphologically and antigenically different to other circoviruses such as Porcine circovirus (PCV) and Psittacine beak and feather disease virus (PBFDV).		Link to Article
What family does the Chicken anaemia virus (CAV) belong to?	Circoviridae		Link to Article
What chemicals destroy the virus?	Hypochlorite and iodophor (formalin only reduces its infectivity).		Link to Article
How many proteins does CAV produce?	Three: Non-enveloped icosahedral single stranded DNA (ssDNA) virus VP1 (52kDA) - structural protein; intracellular form of the capsid protein VP2 (24 kDA) - found in small amounts in the purified virus VP3 (14 kDA) - involved in apoptosis (programmed and controlled cell death with no lysis of the cell. Causes apoptosis of infected stem cells in the bone marrow (BM). Sequential damage to BM inhibits the production of red blood cells (RBC), white blood cells (WBC), lymphoid tissue and platelets. Vaccines need to contain both VP1 and VP2 to be antigenic. Due to VP3 apoptotic properties it has the potential to be an anti-cancer agent.		Link to Article
Is Chicken anaemia virus disease considered to be a zoonosis?	No		Link to Article
What species of birds does the CAV infect?	Chickens (but can also affect quail). The disease severely affects 10-14 day old chicks.		Link to Article
What are the clinical signs of Chicken Anaemia Virus Disease?	Clinical signs are dependent on the age of the bird. Chicks develop clinical signs within two weeks of hatching if infected via vertical transmission. Chicks older than 14 days old do not show any clinical signs if infected via horizontal transmission. Clinical signs include: Pale; comb, wattle, eyelids, legs and carcass, *Anorexia, weight loss, stunting, and unthriftiness Cyanosis, petechiation and ecchymoses, Weakness, lethargy and sudden death. Neurological signs include: Dullness Depression Paresis		Link to Article
What species of birds does the CAV infect?	Chickens (but can also affect quail). The disease is more severe in chicks.		Link to Article
What species of birds does the CAV infect?	Chickens (but can also affect quail). The disease is more severe in chicks.		[[Chicken Anaemia Virus Disease#Signalment Fomites may assist the transmission of the virus. Immunity occurs once the bird has become infected.|Link to Article]]
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