- Azoturia (Monday morning disease)
- Acute
- Due to exercise following a prolonged period of rest
- Clincal signs:
- Unable to move
- Sweating
- Tremors
- Swollen and hard lumbar, gluteal and femoral muscles
- Myoglobin leaks from muscle cells -> leaks into urine -> urine is dark red/brown (myoglobinuria) -> damages renal tubules
- Grossly:
- Salmon pink muscles -> dark, moist, swollen +/- pale streaks
- Histologically:
- Segmental myofibre necrosis
- Multifocal and monophasic, but may be multiphasic if repeated bouts
- Both, type IIA and IIB fibres affected; type IIB preferentially affected in acute disease
- Minor inflammatory reaction and calcification
- Segmental myofibre necrosis
- Tying-up
- Similar to azoturia but much milder
- Grossly - normal muscle
- Histologically - same as azoturia