Cognitive Dysfunction Syndrome

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(CDS)

  • CDS causes signs of senility.
  • Increasing numbers of dogs and cats are suffering from CDS.
    • Prevalence is similar to that seen in humans: an 85 year-old human is roughly equivalent to a 15 year-old cat, and a 13-14 year-old dog.
      • Aging in dogs is breed specific.

Pathology

  • A number of changes are seen in the brains of geriatric animals which may cause the signs of CDS.
    • Vascular insufficiency leads to:
      • Hypoxia
      • Increased free redical production
      • Deposition of amyloid plaques
      • Modification of other brain proteins

Treatment

  • There are no published studies related to treatment of CDS in animals.
  • Potential therapies include:
    • Dietary modification
      • Diets are enriched with antioxidants, vitamin E, beta-carotene and essential fatty acids.
    • Environmental stimulation
    • Drugs
      • Selegiline
      • Propentofylline
      • Nicergoline

Also see: Feline Cognitive Dysfunction