Immunoglobulins Flashcards

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IMMUNOGLOBULINS
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Immunoglobulins Structure and Function

Question Answer Article
What are immunoglobulins also known as?
  • Antibodies
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How many domains does the heavy chain have?
  • 1 variable domain
  • 3 or 4 constant domains
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How many domains does the light chain have?
  • 1 variable domain
  • 1 constant domain
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What are hypervariable domains?
  • Folded pockets of the variable domain into which antibody can bind
  • Different antibodies have different amino acid sequences within the three variable domains
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What does Fab stand for and from which chain is it generated?
  • Fragment associated with antigen binding
  • Light chain
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What does Fc stand for and from which chain is it generated?
  • Constant fragment
  • Heavy chain
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What does the Fc fragment do?
  • Mediates phagocytosis
  • Triggers inflammation
  • Targets Ig to certain tissues
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What are the four major effects of antibodies?
  • Blockage and agglutination
  • Promotion of phagocytosis
  • Degranulation of mast cells/eosinophils
  • Complement Fixation
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Immunoglobulins Classes

Question Answer Article
What are immunoglobulins also known as?
  • Antibodies
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Immunoglobulins Variation

Question Answer Article
What are immunoglobulins also known as?
  • Antibodies
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