Flaviviridae

VIRUSES

Introduction

This group of viruses has three distinct genera, two of which are of veterinary concern. Flaviviruses, which are endemic vector-borne neurotropic viruses, include louping ill and West Nile Virus. Pestiviruses include Swine Fever and Bovine Virus Diarrhoea and present more hemorrhagic disease. Hepatitis C in man is also grouped in this classification.

Morphology

• Medium sized enveloped viruses

Types and Subtypes

Pestiviruses

Bovine Viral Diarrhoea & Mucosal Disease Virus may also contribute to Enzootic pneumonia of calves, may cause growth retardation lattice

Swine Fever Virus

• Border Disease
  • In sheep
  • Virus crosses placenta
  • Tropism for foetal lymphoid, hair follicle and CNS tissue
  • Lambs born weak, small
  • Hairy shaker syndrome
  • Hair rather than wool coats and cerebellar hypoplasia