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Immunity to Fungi

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Cutaneous and superficial fungal infections are normally self-limiting, with recovery associated with a resistance to re-infection. As hosts often develop delayed-type hypersensitivity, this resistance appears to be cell-mediated.

  • T cell immunity- it is thought that helper T cells release cytokines to activate macrophages to fight the infection
  • Neutrophils- there is now growing evidence for the role of neutrophils in some infections of the respiratory system, with defensin and the nitric oxide pathways implicated
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