- Infectious necrotic hepatitis/black disease:
- Acute disease of sheep, occasionally cattle
- Hepatic necrosis caused by exotoxins of C. novyi type B in liver damaged by Fasciola hepatica
- Rapid death
- Dark discoloration of skin caused by subcutaneous venous congestion
- Fluorescent antibody test diagnostic
- Causes gas gangrene and myositis.
- May be involved in cutaneous lesions
- Causes big head in rams - oedema of subcutaneous tissues of the head, neck and cranial thorax; necrotising lethal alpha toxin