• Hypertrophy of epidermis, particularly at pressure points
  • Usually affects giant breed dogs and pigs kept on hard floor
  • May be followed by folliculitis, furunculosis and ulceration
  • Microscopically:
    • Hyperkeratosis and acanthosis or epidermis and follicular epithelium
    • Comedones and follicular cysts may be present, potentially rupture and cause secondary pyoderma
    • Excessive keratin widening follicular openings