Polychlorinated Napthalene Poisoning

Hyperplastic proliferative pathology

• Polychlorinated biphenyl's (PCB's).
• Used in all sorts of things.
• Do not break down in environment and very toxic.
• Poisoning was classically seen as proliferative stomatitis when PCB used to lubricate feed pellet making machine.
• Vitamin A antagonist produces hyperkeratosis of mouth (like Vitamin A deficiency).