Changes

==Pharmacological Considerations==

==Pharmacological Considerations==

Alfaxalone can be administered intravenously and intramuscularly. It is available as either a single agent solution at 10mg/ml, or in combination with alfadolone with polyoxyethylated castor oil as a solvent. It has a rapid onset of action, inducing anaesthesia with 30-60 seconds when given intravenously. Its duration of action is dose dependent.  If given intramuscularly, onset of anaesthesia is within 7-10 minutes. However, it has a varying degree of effect and may only sedate the patient. Recovery is dependent on metabolism via glucuronidation processes, rather then redistribution.  

Alfaxalone is available as either a single agent solution at 10mg/ml, or in combination with alfadolone with polyoxyethylated castor oil as a solvent. Alfaxalone can be administered intravenously and intramuscularly, though the efficacy of intramuscular injection is species dependant - '''do not''' rely on intramuscular injection of alfaxalone to sedate or induce anaesthesia in dogs. It has a rapid onset of action, inducing anaesthesia with 30-60 seconds when given intravenously. Its duration of action is dose dependent.  If given intramuscularly, onset of anaesthesia is within 7-10 minutes. Recovery occurs due to a combination of metabolism via and redistribution.

 

The formulation of alfaxalone in cyclodextrin has a volume of distribution after a single injection of a clinical dose in dogs and cats of 2.4 L/kg and 1.8 L/kg, respectively. In cats, the mean terminal plasma elimination half-life (t1/2) for alfaxalone is approximately 45 minutes for a 5 mg/kg dose. Mean plasma clearance for a 5 mg/kg dose is 25.1 ± 7.6 mL/kg/min. In dogs, the mean terminal plasma elimination half-life (t1/2) for alfaxalone is approximately 25 minutes for a 2 mg/kg dose. Plasma clearance for a 2 mg/kg dose is 59.4 ± 12.9 mL/kg/min. (Product literature)

 

Alfaxalone in cyclodextrin has been used safely after administration of an extremely wide range of premedication and peri-operative drugs.  Dose dependant CNS depression can be accentuated by administration of sedatives and analgesics.  Alfaxalone should not be administered concurrently with other intravenous anaesthetic induction drugs, but has been used safely as an induction agent prior to maintenance with halothane, isoflurane, sevoflurane and desflurane. It should not be mixed in the same syringe as other medications, as the cyclodextrin has a propensity to bind other chemicals.  If a need exists to dilute the alfaxalone in cyclodextrin solution, it has been shown to be stable in 0.9% Saline for up to 7 days.  Slight absorbtion to plastic of giving sets has been recognised, though this appears to be of no clinical significance.

==Contraindications and Side Effects==

==Contraindications and Side Effects==

===Cardiovascular Effects===

===Cardiovascular Effects===

*Dose dependent decrease in arterial blood pressure thought to be due to myocardial contractility and stroke volume.  

*At clinical doses, and employing the concepts of balanced anaesthesia, alfaxalone in cyclodextrin causes little cardiovascular effect, however a dose dependent decrease in arterial blood pressure thought to be due to myocardial contractility and stroke volume can be recognised at supra-clinical doses.

===Respiratory Effects===

===Respiratory Effects===

===Other Effects===

===Other Effects===

*Histamine release leading to swollen paws and face of dogs that have received agents in polyoxyethylated castor oil. This also makes it contraindicated in cats with asthma or mast cell tumours.

*The combination product (alfaxalone/aldalone) solubilised in Cremohpor EL has been associated with histamine release leading to swollen paws and face, erythema and anaphylactoid reactions in dogs and cats, also making it contraindicated in cats with asthma or mast cell tumours. This is not experienced with the aqueous cyclodextrin formulation of alfaxalone

==Uses==

==Uses==

Alfaxalone can be used for induction of anaesthesia in dogs and cats.

Alfaxalone can be used for induction and maintenance of anaesthesia in dogs and cats.