Changes

Amyloidosis causes soluable proteins to polymerise into insoluable fibrils resulting in chronic infections and impaired renal function. This condition frequently in older (>1) female hamsters.

Amyloidosis causes soluable proteins to polymerise into insoluable fibrils resulting in chronic infections and impaired renal function. This condition frequently in older (>1) female hamsters.

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Macroscopic histology include rough, pale and enlarged kidneys, enlarged adrenal glands and liver at necropsy. Microscopic histopathology may include glomerular hyalinisation, amyloid deposits in tubules and amyloid deposits in other organs including the spleen, liver and adrenals. Microscopic histopathology can be easily visualised with Congo red stain.

Macroscopic histology includes rough, pale and enlarged kidneys, enlarged adrenal glands and liver at necropsy. Microscopic histopathology may include glomerular hyalinisation, amyloid deposits in tubules and amyloid deposits in other organs including the spleen, liver and adrenals. Microscopic histopathology can be easily visualised with Congo red stain.

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===Arteriolar Nephrosclerosis (Hamster Nephrosis)===

===Arteriolar Nephrosclerosis (Hamster Nephrosis)===

Arteriolar nephrosclerosis is a degenerative disease occurring most commonly in older hamsters, particularly females. Clinical symptoms will include weight loss and polyuria/polydipsia. Some links have been made between this disease and 'Lymphocytic choriomeningitis' virus infections (see below) which results in renal vascular hypertension. Arteriolar nephrosclerosis may also be concurrent with amyloidosis (above).  

Arteriolar nephrosclerosis is a degenerative disease occurring most commonly in older hamsters, particularly females. Clinical symptoms will include weight loss and polyuria/polydipsia. Some links have been made between this disease and 'Lymphocytic choriomeningitis' virus infections (see below) which results in renal vascular hypertension. Arteriolar nephrosclerosis may also be concurrent with amyloidosis (above).