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'''Clostridial Enteritis'''

'''Clostridial Enteritis'''

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''Clostridium perfringens, [[C._difficile|C. difficile]]'' and ''C. spireforme'' produce toxins causing oedema, haemorrhage, mucosal dysfunction and necrosis. Clostridial enteritis manifests as 2 syndromes. The first is acute diarrhoea that is likely to have been caused by dietary changes, antibiotic therapy, concurrent diseases or physiological stresses. The second manifestation occurs in older (>6months) hamsters where they slowly loose weight and condition and die without diarrhoea.<br />

''Clostridium perfringens, [[C._difficile|C. difficile]]'' and ''C. spiroforme'' produce toxins causing oedema, haemorrhage, mucosal dysfunction and necrosis. Clostridial enteritis manifests as 2 syndromes. The first is acute diarrhoea that is likely to have been caused by dietary changes, antibiotic therapy, concurrent diseases or physiological stresses. The second manifestation occurs in older (>6months) hamsters where they slowly loose weight and condition and die without diarrhoea.<br />

Acute diarrhoea is macroscopically diagnosed at necropsy by serosal and mucosal haemorrhages of the cecum and sometimes the lower intestine. Definitive diagnosis for either manifestation is made via bacterial culture. The second manifestation is diagnosed macroscopically via a thickening of the cecal wall containing inflammatory cell infiltrate.  

Acute diarrhoea is macroscopically diagnosed at necropsy by serosal and mucosal haemorrhages of the cecum and sometimes the lower intestine. Definitive diagnosis for either manifestation is made via bacterial culture. The second manifestation is diagnosed macroscopically via a thickening of the cecal wall containing inflammatory cell infiltrate.  

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