− | IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and basophils, causing degranulation. It is involved in type I hypersensitivity reactions. Cross-linking of IgE molecules by antigens, triggers mast cell degranulation and an inflammatory response. IgE has considerable involvement in producing immunity to parasitic worms, particularly nematode parasites. It may mediate their expulsion or killing via mast cell activity, cytotoxic eosinophils, macrophages, and so on. | + | IgE triggers acute inflammation by binding to the FCεRI receptors on mast cells in the lamina propria and [[Basophils|basophils]], causing degranulation. It is involved in [[Type I Hypersensitivity|type I hypersensitivity reactions]]. Cross-linking of IgE molecules by antigens, triggers [[Mast Cells|mast cell]] degranulation and an inflammatory response. IgE has considerable involvement in producing immunity to parasitic worms, particularly [[:Category:Nematodes|nematode]] parasites. It may mediate their expulsion or killing via mast cell activity, cytotoxic [[Eosinophils|eosinophils]], [[Macrophages|macrophages]], and so on. |