Changes

*Severe respiratory distress with laboured breathing and grunting on expiration

*Severe respiratory distress with laboured breathing and grunting on expiration

*Can result in [[Diffuse Fibrosing Alveolitis|diffuse fibrosing alveolitis]]

*Can result in [[Diffuse Fibrosing Alveolitis|diffuse fibrosing alveolitis]]

*Gross appearance is that of enlarged wet lungs, the interlobular septa are markedly widenedith [[Pulmonary Oedema|oedema]] and [[Lungs Ventilation - Pathology#Emphysema|emphysema]]

*Gross appearance is that of enlarged wet lungs, the interlobular septa are markedly widenedith [[Pulmonary Oedema|oedema]] and [[Pulmonary Emphysema|emphysema]]

*Underlying pathogenesis is ingestion of L-tryptophan in the pasture which is metabolised to 3-methylindole  -> bloodstream -> lungs -> metabolised into a compound toxic to Type 1 pneumonocytes and non-ciliated bronchiolar epithelium

*Underlying pathogenesis is ingestion of L-tryptophan in the pasture which is metabolised to 3-methylindole  -> bloodstream -> lungs -> metabolised into a compound toxic to Type 1 pneumonocytes and non-ciliated bronchiolar epithelium

*Their loss allows massive flooding of the alveoli with a protein-rich fluid

*Their loss allows massive flooding of the alveoli with a protein-rich fluid

*Lesions can vary from interstitial to [[Bronchitis|chronic bronchitis]] to [[Lungs Inflammatory - Pathology#Granulomatous pneumonia|granulomatous pneumonia]]

*Lesions can vary from interstitial to [[Bronchitis|chronic bronchitis]] to [[Lungs Inflammatory - Pathology#Granulomatous pneumonia|granulomatous pneumonia]]

*May be infiltrate of eosinophils in pulmonary interstitium and bronchoalveolar spaces

*May be infiltrate of eosinophils in pulmonary interstitium and bronchoalveolar spaces

*[[Lungs Ventilation - Pathology#Atelectasis (Collapse)|Atelectasis]] and [[Lungs Ventilation - Pathology#Emphysema|emphysema]] may result due to obstruction

*[[Atelectasis|Atelectasis]] and [[Pulmonary Emphysema|emphysema]] may result due to obstruction

=Stages of pneumonia=

=Stages of pneumonia=