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[[Image:LH Basophil Histology.jpg|thumb|right|150px|<p><b>Basophil</b></p><sup>©RVC 2008</sup>]] [[Image:LH Avian Basophil Histology.jpg|thumb|right|150px|<p><b>Avian Basophil</b></p><sup>©RVC 2008</sup>]]
[[Image:LH Basophil Histology.jpg|thumb|right|150px|<p><b>Basophil</b></p><sup>©RVC 2008</sup>]] [[Image:LH Avian Basophil Histology.jpg|thumb|right|150px|<p><b>Avian Basophil</b></p><sup>©RVC 2008</sup>]]
== Introduction ==
== Introduction ==
Basophils are derived from the same stem cell line as [[Mast Cells|mast cells]] and while they are similar to mast cells, they are not identical (they are thought by some to be immature mast cells). They are the least common of all the [[Leukocytes|leukocytes]], are a similar size to neutrophils and eosinophils and are characterised by the large number of basophilic staining granules in their cytoplasm. They are present in the circulation but rarely found in tissue.
Basophils are derived from the same stem cell line as [[Mast Cells|mast cells]] and while they are similar to mast cells, they are not identical (they are thought by some to be immature mast cells). They are the least common of all the [[Leukocytes|leukocytes]], are a similar size to neutrophils and eosinophils and are characterised by the large number of basophilic staining granules in their cytoplassm. They are present in the circulation but rarely found in tissue.
== Development ==
== Development ==
The basophil is a [[Blood Cells - Overview|granulocyte]] and has a similar development to the other granulocytes. This process is called [[Leukopoiesis#Granulopoiesis|granulopoiesis]].
The basophil is a [[Blood Cells - Overview|granulocyte]] and has a similar development to the other granulocytes. This process is called [[Leukopoiesis#Granulopoiesis|granulopoiesis]].
== Granules ==
== Granules ==
Two types of granules are present in basophils:
Two types of granules are present in basophils:
*Specific granules contain heparin, histamine, leukotrienes and some lysosomes. Heparin has anti-coagulative capabilities and is also involved in assisting lipid uptake from the blood after meals. Histamine causes vasodilation.
*Specific granules contain heparin, histamine, leukotrienes and some lysosomes. Heparin has anti-coagulative capabilities and is also involved in assisting lipid uptake from the blood after meals. Histamine causes vasodilation.
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== Actions ==
Fc receptors on the basophil surface binds with IgE formed during allergic reactions and causes them to degranulate. The vasoactive substances released from the granules causes vasodialtion allowing for the infiltration of other leukocytes i.e. [[Neutrophils#Movement|neutrophil diapedesis]].
=== Role in pathology ===
=== Role in pathology ===
*Classically a cell involved in [[Acute Inflammation|acute inflammation]]
*Classically a cell involved in [[Acute Inflammation|acute inflammation]]
== Interactions ==
== Interactions ==
*[[IgE]] and CD40 receptors on the basophils interact with B cells to increase [[IgE]] production
*[[IgE]] and CD40 receptors on the basophils interact with B cells to increase [[IgE]] production
*[[Complement]] factor C3a binds to the basophil and causes degranulation
*[[Complement]] factor C3a binds to the basophil and causes degranulation
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[[Category:Blood_Cells]] [[Category:Kate English reviewing]]
[[Category:Blood_Cells]] [[Category:Kate_English_reviewing]]