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== Introduction ==

== Introduction ==

Coccidiosis is a disease of poultry which is of worldwide importance, both economically and for animal welfare reasons. It is a disease of over-crowding and poor hygiene, hence it is prevalent in intensive chicken farming globally, however, it can affect birds in any facilities. Although outbreaks of the disease are not common, coccidia remians in most flocks as a subclinical disease, which in times of stress can establish into a clinical disease. Many commercial units now use prophylactic drugs in order to try and control the disease.

Coccidiosis is a disease of poultry which is of worldwide importance, both economically and for animal welfare reasons. It is a disease of over-crowding and poor hygiene, hence it is prevalent in intensive chicken farming globally, however, it can affect birds in any facilities. Although outbreaks of the disease are not common, coccidia remians in most flocks as a subclinical disease, which in times of stress can establish into a clinical disease. Many commercial units now use prophylactic drugs in order to try and control the disease.  

There are&nbsp;7 important coccidia species in chickens, all which fall into the Eimeria genus.&nbsp;<br>There are 4 malabsorptive species, which range from low to moderate pathogenicity&nbsp;and 3 haemorrhagic species, which are all highly pathogenic. All seven species have different predilection sites in the alimentary system and cause unique pathological changes.

There are&nbsp;7 important coccidia species in chickens, all which fall into the Eimeria genus.&nbsp;<br>There are 4 malabsorptive species, which range from low to moderate pathogenicity&nbsp;and 3 haemorrhagic species, which are all highly pathogenic. All seven species have different predilection sites in the alimentary system and cause unique pathological changes.  

'''Epidemiology'''<br>Oocysts are ubiquitous and robust and can survive several months to several years in the environment, meaning it is almost impossible to keep buildings free from infection. Even with strong disinfection after every batch has gone, the new chicks will become infected by pecking the ground shortly after being placed in the poultry house.<br>The biotic potential is enormous and generation time is short, meaning infections can build up rapidly. Immuntiy however, develops slowly and certain species of Eimeria will inflict a faster immune response and longer lasting immunity than others.

== Clinical Signs ==

== Clinical Signs ==

Depends on the pathogenicity of the coccidia involved and the concurrent health status of the chicken.

Depends on the pathogenicity of the coccidia involved and the concurrent health status of the chicken.  

With any infection will usually see depression, general malaise, reluctance to eat, weight loss and sudden death. Often the only sign will be sudden death in severe cases. In most cases of coccidiosis, there will be&nbsp;a watery or mucoid diarrhoea which will often be blood-tinged.

With any infection will usually see depression, general malaise, reluctance to eat, weight loss and sudden death. Often the only sign will be sudden death in severe cases. In most cases of coccidiosis, there will be&nbsp;a watery or mucoid diarrhoea which will often be blood-tinged.  

As clinical signs can vary, the most useful diagnostic tool is&nbsp;a necropsy&nbsp;on a recently dead bird that has been sacrificed for this purpose. A bird that has died naturally and has been dead for over one hour will make post mortem examination difficult due to post mortem changes in the intestinal mucosa.  

 

As clinical signs can vary, the most useful diagnostic tool is&nbsp;a necropsy&nbsp;on a recently dead bird that has been sacrificed for this purpose. A bird that has died naturally and has been dead for over one hour will make post mortem examination difficult due to post mortem changes in the intestinal mucosa.

The presence of coccidia and mild lesions are present in most young birds between the age of 3- 6 weeks of age but do not mean the bird has clinical coccidiosis. The severity of the lesions should determine a diagnosis of coccidiosis being made.  

The presence of coccidia and mild lesions are present in most young birds between the age of 3- 6 weeks of age but do not mean the bird has clinical coccidiosis. The severity of the lesions should determine a diagnosis of coccidiosis being made.  

Lesions and their location vary depending on which Eimeria genus is causing the disease:  

Lesions and their location vary depending on which Eimeria genus is causing the disease:  

''[[Eimeria spp.|Eimeria]] acervulina:'' proximal gut, thickened walls, 'white ladder lesions' produced by dense foci of gamonts and oocysts and a watery exudate are likely to be found in this case.<br>''[[Eimeria spp.|Eimeria]] maxima: ''mid-gut, thickened walls and a pink exudate with this coccidia.<br>''[[Eimeria spp.|Eimeria]] tenella: s''wollen [[Caecum - Anatomy & Physiology|caeca]], thickened intestinal walls, dark colouring of damaged intestine&nbsp;containing a core of necrotic tissue and blood.<br>''[[Eimeria spp.|Eimeria]] necatrix: ''mid-gut, the wall will show 'ballooning', white spots and petechiae form characteristic&nbsp;'salt and pepper' lesions and there will be haemorrhage into lumen.

''[[Eimeria spp.|Eimeria]] acervulina:'' proximal gut, thickened walls, 'white ladder lesions' produced by dense foci of gamonts and oocysts and a watery exudate are likely to be found in this case.<br>''[[Eimeria spp.|Eimeria]] maxima: ''mid-gut, thickened walls and a pink exudate with this coccidia.<br>''[[Eimeria spp.|Eimeria]] tenella: s''wollen [[Caecum - Anatomy & Physiology|caeca]], thickened intestinal walls, dark colouring of damaged intestine&nbsp;containing a core of necrotic tissue and blood.<br>''[[Eimeria spp.|Eimeria]] necatrix: ''mid-gut, the wall will show 'ballooning', white spots and petechiae form characteristic&nbsp;'salt and pepper' lesions and there will be haemorrhage into lumen.  

 

 

For more information see [[Anti-Protozoal Drugs|here]]

Prevention of this disease is much more valuable than treatment should an outbreak occur. In commercial poultry farms, many measures are undertaken to control the disease. Intensive poultry production is largely dependent on the use of anticoccidial drugs, as well as strict hygiene controls.

'''Layers<br>[[Vaccines|Vaccines]]&nbsp;are used for laying hens as these have a longer life span than broilers so will develop an immunity.

For more information see [[Anti-Protozoal Drugs|here]]  

Paracox 7&nbsp;vaccine is a multivalent attenuated [[Vaccines#What_antigen.28s.29_do_we_use_in_the_vaccine.3F|live vaccine]] for replacement layers, which contains 7 live strains of ''[[Eimeria spp.|Eimeria]]. ''These live strains lack the most pathogenic life cycle stage making the prepatent period shorter. These are known as '''precocious''' strains.

'''Layers<br>'''[[Vaccines|Vaccines]]&nbsp;are used for laying hens as these have a longer life span than broilers so will develop an immunity'''.'''  

Chicks are&nbsp;[[Vaccines|vaccinated]] on a single occasion when they are&nbsp;1-9 days old through oocyst suspension in the feed or water. For a short period, v[[Vaccines|accinated]] birds have sub-optimal growth rates so&nbsp;this is why they are not used for&nbsp;broilers.

Paracox 7&nbsp;vaccine is a multivalent attenuated [[Vaccines#What_antigen.28s.29_do_we_use_in_the_vaccine.3F|live vaccine]] for replacement layers, which contains 7 live strains of ''[[Eimeria spp.|Eimeria]]. ''These live strains lack the most pathogenic life cycle stage making the prepatent period shorter. These are known as '''precocious''' strains.  

'''Broilers<br>'''As broilers have a much shorted life span than laying hens, vaccination is not the most economical option in this case.  

'''Broilers<br>'''As broilers have a much shorted life span than laying hens, vaccination is not the most economical option in this case.  

The continuous use of a single anti-coccidial&nbsp;drug from day one of life through to slaughter is used. As the broiler does not live for long, immunity would not have time to develop so providing anti-coccidial drugs on a constant basis controls the disease well.

The continuous use of a single anti-coccidial&nbsp;drug from day one of life through to slaughter is used. As the broiler does not live for long, immunity would not have time to develop so providing anti-coccidial drugs on a constant basis controls the disease well.  

 

 

 

Strict hygiene measures in both layers and broilers is needed to control coccidia. Litter should be removed and the housing thoroughly disinfected between crops. The ideal turnaround should be no less than 10 days, but this often is impracticable for economic reasons. Over-crowding exacerbates coccidiosis, so the lowest stocking density which is compatible with economic production should be used.<br>Water bowls, roofs and walls should be well maintained to prevent litter becoming damp and sttress factors should be avoided and adequate nutrition provided.

A vaccine called Paracox 5, which contains 5 strains of the most pathogenic ''[[Eimeria spp.|Eimeria]]&nbsp;''can be used for broilers. It is sprayed onto the first feed offered to new batches of chicks and will provide integrated control. Careful management throughout is required so in-feed prophylaxis and [[Vaccines|vaccination]] do not fail.  

== References ==

== References ==

Fox, M and Jacobs, D. (2007) Parasitology Study Guide Part 1: Ectoparasites Royal Veterinary College <br>Jordan, F, Pattison, M, Alexander, D, Faragher, T, (1999) Poultry Diesease (Fifth edition) W.B. Saunders<br>Merck &amp; Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial<br>Randell, C.J, (1985) Disease of the Domestic Fowl and Turkey, Wolfe Medical Publication Ltd<br>Saif, Y.M, (2008) Disease of Poultry (Twelfth edition) Blackwell Publishing<br>

Fox, M and Jacobs, D. (2007) Parasitology Study Guide Part 1: Ectoparasites Royal Veterinary College <br>Jordan, F, Pattison, M, Alexander, D, Faragher, T, (1999) Poultry Diesease (Fifth edition) W.B. Saunders<br>Merck &amp; Co (2008) The Merck Veterinary Manual (Eighth Edition) Merial<br>Randell, C.J, (1985) Disease of the Domestic Fowl and Turkey, Wolfe Medical Publication Ltd<br>Saif, Y.M, (2008) Disease of Poultry (Twelfth edition) Blackwell Publishing<br>

== Literature Search ==

== Literature Search ==

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[[Image:CABI logo.jpg|left|90px]]