Changes

*Presenting signs:

**[[Bones Fractures - Pathology#Fracture classification|Pathological fracture]]

**Hypercalcaemia  

***Due to resorption of bone

'''Presenting signs:'''

:[[Fractures#Fracture classification|Pathological fracture]]

*Most present with both,  

**Bone resorption  

:[[Hypercalcaemia]] - due to resorption of bone

**New bone formation

 

***In response to stress on the cortex

Most patients present with both, bone resorption and new bone formation in response to stress on the cortex. New bone formation occurs mostly in neoplasms with fibrous stroma and minimally in e.g lymphosarcoma, myeloma.

***Mostly in neoplasms with fibrous stroma, minimal in e.g lymphosarcoma, myeloma

 

 

[[Category:Bones - Pathology]]

[[Category:Bones - Pathology]]