Author, Donkey, Bureaucrats, Administrators
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Created page with "*'''Plants''' **E.g. ''Cassia occidentalis'' (coffee senna), ''Karwinskia humboldtiana'' (coyotillo), ''Eupatorium rugosum'' (white snakeroot), cotton seed **Lesion an skeletal ..."
*'''Plants'''
**E.g. ''Cassia occidentalis'' (coffee senna), ''Karwinskia humboldtiana'' (coyotillo), ''Eupatorium rugosum'' (white snakeroot), cotton seed
**Lesion an skeletal and cardiac muscle
**Grossly:
***Pale areas with ill-defined borders
***May involve very extensive [[Muscles Degenerative - Pathology#Necrosis|necrosis]]
**Histologically:
***Segmental necrosis, no calcification
***[[Muscle Regeneration|Regeneration]] may occur in surviving animals
*'''Drugs'''
**E.g. corticosteroids, cholinesterase inhibitors, vincristine, dimethyl sulfoxide (DMSO)
**'''Monensin''' is a coccidiostat toxic to horses, donkeys, zebras, cattle, sheep, dogs and birds
***Causes muscle necrosis in heart and skeletal muscle
***Grossly:
****Pale streaks, mostly in hind limbs
***Histologically:
****[[Muscles Degenerative - Pathology#Necrosis|Segmental necrosis]]
****Possibly [[Muscle Regeneration|regeneration]] in surviving animals
***Can cause rapid onset recumbency and potentially death
***Usually due to mixing errors in feed
**Also from intramuscular injections, e.g. oxytetracycline, lidocaine, chloramphenicol, produce local necrosis
***As satellite cells are destroyes, repair is via fibrosis with some budding
*'''Chemicals'''
**Iron injections can cause local myonecrosis
*'''Mycotoxins'''
**Metabolites cause persistent tremors
**Lesions in skeletal muscle only, possibly secondary to sustained contractions (similar to [[Muscles Degenerative - Pathology#Exertional myopathies|exertional myopathy]])
**Histologically:
***Tiny foci of [[Muscles Degenerative - Pathology#Necrosis|segmental necrosis]]
[[Category:Muscles - Degenerative Pathology]]
**E.g. ''Cassia occidentalis'' (coffee senna), ''Karwinskia humboldtiana'' (coyotillo), ''Eupatorium rugosum'' (white snakeroot), cotton seed
**Lesion an skeletal and cardiac muscle
**Grossly:
***Pale areas with ill-defined borders
***May involve very extensive [[Muscles Degenerative - Pathology#Necrosis|necrosis]]
**Histologically:
***Segmental necrosis, no calcification
***[[Muscle Regeneration|Regeneration]] may occur in surviving animals
*'''Drugs'''
**E.g. corticosteroids, cholinesterase inhibitors, vincristine, dimethyl sulfoxide (DMSO)
**'''Monensin''' is a coccidiostat toxic to horses, donkeys, zebras, cattle, sheep, dogs and birds
***Causes muscle necrosis in heart and skeletal muscle
***Grossly:
****Pale streaks, mostly in hind limbs
***Histologically:
****[[Muscles Degenerative - Pathology#Necrosis|Segmental necrosis]]
****Possibly [[Muscle Regeneration|regeneration]] in surviving animals
***Can cause rapid onset recumbency and potentially death
***Usually due to mixing errors in feed
**Also from intramuscular injections, e.g. oxytetracycline, lidocaine, chloramphenicol, produce local necrosis
***As satellite cells are destroyes, repair is via fibrosis with some budding
*'''Chemicals'''
**Iron injections can cause local myonecrosis
*'''Mycotoxins'''
**Metabolites cause persistent tremors
**Lesions in skeletal muscle only, possibly secondary to sustained contractions (similar to [[Muscles Degenerative - Pathology#Exertional myopathies|exertional myopathy]])
**Histologically:
***Tiny foci of [[Muscles Degenerative - Pathology#Necrosis|segmental necrosis]]
[[Category:Muscles - Degenerative Pathology]]