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Glial Cell Response to Injury (view source)
Revision as of 12:33, 8 March 2011
, 12:33, 8 March 2011Created page with "* The order of susceptibility of CNS cells to injury runs, from most to least susceptible: *# Neurons *# Oligodendroglia *# Astrocytes *# Microglia *# Endothelial cells ===Ast..."
* The order of susceptibility of CNS cells to injury runs, from most to least susceptible:
*# Neurons
*# Oligodendroglia
*# Astrocytes
*# Microglia
*# Endothelial cells
===Astrocytes===
* The response of astrocytes to insult include:
** '''Necrosis'''
** '''Astrocytosis'''
*** An increase in the number of astrocytes (i.e. astrocyte hyperplasia).
** '''Astrogliosis'''
*** An increase in the size of astrocytes (i.e. astrocyte hypertrophy).
** '''Gliosis'''
*** Formation of glial fibres.
*** This is a form of scarring in the CNS.
===Oligodendrocytes===
* Oligodendrocytes are prone to hypoxia and degeneration
* Oligodendrocytes proliferate around damaged neurons.
** This is known as '''satellitosis'''.
* Death of oligodendrocytes causes demyelination.
===Microglial Cells===
* Microglial cells can respond in two ways to CNS injury.
*# They may phagocytose cell debris to transform to gitter cells.
*#* Gitter cells are large macrophages with foamy cytoplasm. [http://w3.vet.cornell.edu/nst/nst.asp?Fun=F_KSsrch&kw=GITTER View images courtesy of Cornell Veterinary Medicine]
*# They may form glial nodules.
*#* These are small nodules that occur notably in viral diseases.
[[Category:CNS Response to Injury]]
*# Neurons
*# Oligodendroglia
*# Astrocytes
*# Microglia
*# Endothelial cells
===Astrocytes===
* The response of astrocytes to insult include:
** '''Necrosis'''
** '''Astrocytosis'''
*** An increase in the number of astrocytes (i.e. astrocyte hyperplasia).
** '''Astrogliosis'''
*** An increase in the size of astrocytes (i.e. astrocyte hypertrophy).
** '''Gliosis'''
*** Formation of glial fibres.
*** This is a form of scarring in the CNS.
===Oligodendrocytes===
* Oligodendrocytes are prone to hypoxia and degeneration
* Oligodendrocytes proliferate around damaged neurons.
** This is known as '''satellitosis'''.
* Death of oligodendrocytes causes demyelination.
===Microglial Cells===
* Microglial cells can respond in two ways to CNS injury.
*# They may phagocytose cell debris to transform to gitter cells.
*#* Gitter cells are large macrophages with foamy cytoplasm. [http://w3.vet.cornell.edu/nst/nst.asp?Fun=F_KSsrch&kw=GITTER View images courtesy of Cornell Veterinary Medicine]
*# They may form glial nodules.
*#* These are small nodules that occur notably in viral diseases.
[[Category:CNS Response to Injury]]