'''Ameloblasts''' are cells in the enamel organ which forms the tooth. They secrete '''[[Enamel Organ#Enamel|enamel]]'''.
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Epithelial cells line the inner surface of the enamel organ. '''Ameloblasts''' are derived from epithelium and form a single layer of very long columnar cells that are hexagonal in cross section. They have elongated, basally sited nuclei. They synthesise '''[[Enamel Organ#Enamel|enamel]]''' which forms the '''[[Enamel Organ#Crown|crown]]''' of each tooth. They maintain connections with the newly synthesised '''[[Enamel Organ#Enamel|enamel]]''' through cellular projections called '''Thomes' fibres'''.
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'''[[Enamel Organ#Enamel|Enamel]]''' is acellular so once the connection with the ameloblasts via the '''Thomes' fibres''' is lost (upon eruption), the [[Enamel Organ#Enamel|enamel]] matrix cannot be remodelled.