Changes

== [[Image:Cushings alopecia.jpg|thumb|right|200px|<small><center><b>Cushings Alopecia</b>. Courtesy of A. Jefferies</center></small>]]&nbsp;Synonyms ==

== [[Image:Cushings alopecia.jpg|thumb|right|200px|<small><center><b>Cushings Alopecia</b>. Courtesy of A. Jefferies</center></small>]]&nbsp;Synonyms ==

 

Cushings Disease

Cuchings Disease

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'''Pituitary Dependant Hyperadrenocorticism'''

'''Pituitary Dependant Hyperadrenocorticism [[Image:Chromophobe adenoma.jpg|thumb|right|150px|<small><center><b>Chromophobe Adenoma</b>. Courtesy of A. Jefferies</center></small>]] [[Image:Nodular hyperplasia.jpg|thumb|center|150px|<small><center><b>Adrenal Nodular Hyperplasia</b>. Courtesy of A. Jefferies</center></small>]]  

[[Image:Chromophobe adenoma.jpg|thumb|right|150px|<small><center><b>Chromophobe Adenoma</b>. Courtesy of A. Jefferies</center></small>]] [[Image:Nodular hyperplasia.jpg|thumb|center|150px|<small><center><b>Adrenal Nodular Hyperplasia</b>. Courtesy of A. Jefferies</center></small>]]  

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80-85% cases of Cushings disease show bilateral adrenal hyperplasia due to excess stimuation by ACTH. There is a failure of the negative feedback mechanism at the level of the pituitary and so ACTH is produced in an unregulated fashion. This is thought to occur due to a functional chromophobe cell (Produces ACTH and MSH) neoplasia, although visible macroadenomas are only found in 10-15% cases with this aetiology. Most cases are therefore thought to be microadenomas and may be visualised by histopathological staining of the pituitary.  

80-85% cases of Cushings disease show bilateral adrenal hyperplasia due to excess stimuation by ACTH. There is a failure of the negative feedback mechanism at the level of the pituitary and so ACTH is produced in an unregulated fashion. This is thought to occur due to a functional chromophobe cell (Produces ACTH and MSH) neoplasia, although visible macroadenomas are only found in 10-15% cases with this aetiology. Most cases are therefore thought to be microadenomas and may be visualised by histopathological staining of the pituitary.