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Fluid accumulation within the pericardial sac may lead to fibrous thickening and opacity of the pericardium if prolonged.  Villous proliferation of the serosa will occur due to the irritation caused by the presence of the fluid.
 
Fluid accumulation within the pericardial sac may lead to fibrous thickening and opacity of the pericardium if prolonged.  Villous proliferation of the serosa will occur due to the irritation caused by the presence of the fluid.
 
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Large volumes of fluid within the pericardial sac may cause [[Cardiac Tamponade - Pathology|cardiac tamponade]], a compression of the heart. Side effects associated with the build up of fluid, such as degrees of embarrassment of the function of the heart, depend on the length of time build up of the fluid occurs.  
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Large volumes of fluid within the pericardial sac may cause [[Cardiac Tamponade|cardiac tamponade]], a compression of the heart. Side effects associated with the build up of fluid, such as degrees of embarrassment of the function of the heart, depend on the length of time build up of the fluid occurs.  
 
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