Fluid accumulation within the pericardial sac may lead to fibrous thickening and opacity of the pericardium if prolonged. Villous proliferation of the serosa will occur due to the irritation caused by the presence of the fluid. | Fluid accumulation within the pericardial sac may lead to fibrous thickening and opacity of the pericardium if prolonged. Villous proliferation of the serosa will occur due to the irritation caused by the presence of the fluid. |