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[[Category:To Do - CABI]]
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Also Known As '''''– BPV - Haemadsorbing enteric virus – HADEN'''''
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==Introduction==
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Bovine parvovirus is one of more than 50 species of the '''[[Parvoviridae|parvivirus]] group'''. There are now thought to be three significant species: BPV1, 2 and 3. <ref>Allander, T., Emerson, S. U., Engle, S. E., Purcell, R. H., Bukh, J (2001) A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species. Proc National Academy Sci, USA, 98(12):11609-11614</ref> BPVs are best known for causing '''[[Diarrhoea|diarrhoea]] in neonatal calves''' and also '''respiratory and reproductive disease''' in adult cattle.
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This virus is very resistant to chemical and physical chellenges. Anaerobic microbial digestion in manure appears to inactivate the virus.
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==Distribution==
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'''Worldwide''' - Bovine parvoviruses have been found in every country where herds have been screened.
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BPVs are very efficiently transmitted transplacentally.
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==Signalment==
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Only cattle are naturally infected.
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Pigs can develop antibodies after ingestion of BPV but develop no clinical signs.
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==Clinical Signs==
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'''[[Diarrhoea]]'''
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'''Abortion, birth of weak or stillborn calves'''. Foetuses in the first trimester are most susceptible.
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Cough, dyspnoea, nasal discharge
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Lymphopaenia
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BPV is made worse by '''concurrent GI infections such as coccidiosis'''.<ref>Durham, P. J., Johnson, R. H., Parker, R. J. (1997). Exacerbation of experimental parvoviral enteritis in calves by coccidia and weaning stress. J Vet Med Sci, 59(11):1023-1025</ref>
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==Diagnosis==
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'''Fluorescent Antibody Test (FAT) and PCR''' are commercially available for diagnosis of BPV.
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BPV can be '''isolated in cell cultures''', and via '''haemagglutination, [[ELISA testing|ELISA]] and electron microscopy.'''
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Foetuses aborted due to BPV infection are '''oedematous''' and have increased pleural and peritoneal fluid. '''Intranuclear inclusion bodies''' are seen in the cells of the small intestine, lymph nodes, liver and cerebellum.
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Virus can be detected in foetal adrenals, lungs, spleen, heart and thymus by '''Immunofluorescence''' (IF).
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On post-mortem of infected calves, '''intestinal villous atrophy and fusion and crypt degeneration''' is visible histologically. There is also lymphoid tissue necrosis associated with the intestinal tract and thymus. Small intestine and caecum appear to be preferential sites for BPV infection and replication.
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==Treatment==
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Treatment is usually by vaccination of dams during gestation, see below for details.
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==Control==
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A '''vaccine''' is available against BPV, combined with other gastrointestinal pathogens. It is given in two doses, the first 6-8 weeks prior to parturition followed by another 4-5 week prior to calving.
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Control can be achieved using organic acid based disinfectants also.
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{{Learning
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|literature search = [http://www.cabdirect.org/search.html]
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|flashcards = [[Bovine Parvovirus Flashcards]]
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}}
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==References==
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<references/>
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Animal Health & Production Compendium, '''Bovine Parvovirus datasheet''', accessed 19/06/2011 @ http://www.cabi.org/ahpc/
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Animal Health & Production Compendium, '''Bovine Parvovirus infections''' datasheet, accessed 19/06/2011 @ http://www.cabi.org/ahpc/
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[[Category:To Do - CABI review]]
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