In addition, inadequate water intake can obviously lead to a more concentrated urine. The role vitamin D plays in calcium metabolism in the rabbit is controversial. Some studies indicate that high dietary concentrations of vitamin D along with high dietary calcium concentrations may predispose the rabbit to calcification of the aorta and kidney, but this is not always reproducible. For this pathology to occur, it may be necessary to maintain high concentrations of vitamin D and calcium for prolonged periods or there may be other unknown metabolic or dietary factors involved. | In addition, inadequate water intake can obviously lead to a more concentrated urine. The role vitamin D plays in calcium metabolism in the rabbit is controversial. Some studies indicate that high dietary concentrations of vitamin D along with high dietary calcium concentrations may predispose the rabbit to calcification of the aorta and kidney, but this is not always reproducible. For this pathology to occur, it may be necessary to maintain high concentrations of vitamin D and calcium for prolonged periods or there may be other unknown metabolic or dietary factors involved. |