Author, Donkey, Bureaucrats, Administrators
53,803
edits
Changes
no edit summary
==Introduction==
==Introduction==
Hair growth follows an intrinsic rhythm and is regulated by multiple growth factors, cytokines and local mediators. It is modified by systemic factors and pineal, pituitary, thyroidal, adrenal and reproductive hormones.
Hair growth follows an intrinsic rhythm and is regulated by multiple growth factors, cytokines and local mediators. It is modified by systemic factors and [[Pineal Gland - Anatomy & Physiology|pineal]], [[Pituitary Gland - Anatomy & Physiology|pituitary]], [[Thyroid Gland - Anatomy & Physiology|thyroidal]], [[Adrenal Glands - Anatomy & Physiology|adrenal]] and [[Reproductive Hormones Overview - Anatomy & Physiology|reproductive hormones]].
There is also a seasonal regulation in colour, thickness and length.
There is also a seasonal regulation in colour, thickness and length.
Its main form is '''acquired''', and the main mechanisms for alopecia are presented below.
Its main form is '''acquired''', and the main mechanisms for alopecia are presented below.
==Traumatic/pruritic alopecia==
==Traumatic/Pruritic Alopecia==
Any pruritic dermatosis will cause alopecia due to the behaviour of the animal who will '''scratch, rub itself on objects, overgroom or bite off hair'''.
Any pruritic dermatosis will cause alopecia due to the behaviour of the animal who will '''scratch, rub itself on objects, overgroom or bite off hair'''.
This is a common cause of bilaterally '''symmetrical alopecia in cats'''.
This is a common cause of bilaterally '''symmetrical alopecia in cats'''.
==Non-traumatic==
==Non-Traumatic==
===Secondary inflammatory===
===Secondary Inflammatory===
Any marked epidermal or dermal inflammatory disease which does not selectively target the hair follicles can still '''damage adjacent hair follicles''' and lead to alopecia. Examples include leishmaniasis or dermal neoplasia.
Any marked epidermal or dermal inflammatory disease which does not selectively target the hair follicles can still '''damage adjacent hair follicles''' and lead to alopecia. Examples include [[Leishmania|leishmaniasis]] or dermal neoplasia.
Scarring can also lead to alopecia through follicular destruction or displacement.
Scarring can also lead to alopecia through follicular destruction or displacement.
'''Follicular infections''' include:
'''Follicular infections''' include:
'''Parasites''': ''Demodex'', ''Straelensia'', ''Pelodera''
'''Parasites''': ''[[Demodex]]'', ''Straelensia'', ''Pelodera''
'''Viruses'''
'''Viruses'''
'''Bacteria''': ''Staphylococcal'' pyoderma, ''Dermatophilus congolensis''
'''Bacteria''': ''Staphylococcal'' pyoderma, ''[[Dermatophilus congolensis]]''
'''Fungi''': dermatophitosis (''Microsporum canis, Trichophyton mentagrophytes'')
'''Fungi''': [[dermatophytosis]] (''Microsporum canis, Trichophyton mentagrophytes'')
'''Sterile folliculitis''' includes cases of: sebaceous adenitis, alopecia areata, idiopathic lymphocytic mural folliculitis, linear alopecia
'''Sterile folliculitis''' includes cases of: [[Sebaceous Adenitis|sebaceous adenitis]], alopecia areata, idiopathic lymphocytic mural folliculitis, linear alopecia
===Non-inflammatory===
===Non-inflammatory===
These diseases tend to slow of inhibit follicular growth.
These diseases tend to slow of inhibit follicular growth. On histopathology, there is telogen and catagen growth with very few hairs in anagen. There is possible atrophy of the follicular epithelium and adnexae and varying degrees of surface and follicular hyperkeratosis.
'''Coat Colour-Linked''':
:Colour-dilution alopecia, black hair dysplasia, follicular lipidosis
'''Endocrine-Related Hair Cycle Problems''':
:[[Hypothyroidism]], [[hyperadrenocorticism]], testicular cell tumours
'''Miscellaneous Hair Cycle Problems'''
:Post-clipping alopecia, traction alopecia, pattern alopecia, cyclic flank alopecia, alopecia X, mane and tail dystrophy
'''Ischaemic/Atrophic'''
:Post-rabies vaccine, dermatomyositis, topical glucocorticoid-induced, paraneoplastic syndrome
'''Neoplastic'''
:Epitheliotropic lymphoma
'''Nutritional/Metabolic/Debilitation/Toxicosis'''
:Iodism, plant toxicoses, selenium, anhidrosis, starvation, chronic hepatic/renal disease
==Clinical Signs==
==Clinical signs==
The signs can be '''obvious or subtle''', depending on the disease. Congenital hair loss is often symmetrical and not accompanied by any inflammatory changes.
The signs can be '''obvious or subtle''', depending on the disease. Congenital hair loss is often symmetrical and not accompanied by any inflammatory changes.
In acquired alopecia, the clinical signs are influenced by the cause. The alopecia can be '''localised, multifocal, symmetric or generalised'''.
In acquired alopecia, the clinical signs are influenced by the cause. The alopecia can be '''localised, multifocal, symmetric or generalised'''.
Inflammatory changes such as: '''lichenification, hyperpigmentation, erythema, scaling and pruritus''' are common. Some causes of alopecia predispose animals to developing '''secondary skin diseases''' such as bacterial pyoderma or seborrhoea.
Inflammatory changes such as: '''lichenification, hyperpigmentation, erythema, scaling and pruritus''' are common. Some causes of alopecia predispose animals to developing '''secondary skin diseases''' such as bacterial pyoderma or [[seborrhoea]].
In '''endocrine disorders''', the pattern of loss is symmetrical, often in wear areas first, and pruritus is not generally present.
In '''endocrine disorders''', the pattern of loss is symmetrical, often in wear areas first, and pruritus is not generally present.
==Diagnostic tests==
==Diagnosis==
A thorough history and physical examination are very important.
A thorough history and physical examination are very important.
Diagnostic tests:
Diagnostic tests:
:'''Skin scrapings''': for ectoparasites (especially ''Demodex'')
'''Skin scrapings''': for ectoparasites (especially ''Demodex'')
:'''Hair brushings''': for [[Fleas|fleas]], [[:Category:Mites|mites]], [[:Category:Lice|lice]]
:'''Tape strips''' for bacterial or yeast infections
'''Hair brushings''': for fleas, mites, lice
:'''Fungal culture''' for evidence of [[ringworm]]
:'''Skin biopsy''': if the other tests are normal. The hair follicles and structures can be examined and any inflammatory patterns can be noted.
'''Tape strips''' for bacterial or yeast infections
:'''Haematology and biochemistry''' are helpful in the diagnosis of endocrinopathies, and specific '''endocrine function tests''' should be performed if such a disease is suspected.
'''Fungal culture''' for evidence of ringworm
'''Skin biopsy''': if the other tests are normal. The hair follicles and structures can be examined and any inflammatory patterns can be noted.
'''Haematology and biochemistry''' are helpful in the diagnosis of endocrinopathies, and specific '''endocrine function tests''' should be performed if such a disease is suspected.
==Treatment==
==Treatment==
Kahn, C. (2005) '''Merck Veterinary Manual''' ''Merck and Co''
Kahn, C. (2005) '''Merck Veterinary Manual''' ''Merck and Co''
{{review}}
[[Category:Dermatological Diseases - Dog]]
[[Category:Dermatological Diseases - Cat]]
[[Category:Integumentary System - Pathology]]
[[Category:Expert Review - Small Animal]]
[[Category:Integumentary System - Developmental Pathology]]
[[Category:Integumentary System - Developmental Pathology]]