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Created page with "{{Template:Manson}} [[Image:|centre|500px]] <br /> '''A ten-year-old entire male Beagle presents with multiple nodular enlargements surrounding the anus. This is associated w..."
{{Template:Manson}}
[[Image:|centre|500px]]
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'''A ten-year-old entire male Beagle presents with multiple nodular enlargements surrounding the anus. This is associated with ulceration and bleeding and is accompanied by a disagreeable odour. Fine needle aspiration is performed and smears prepared (Wright’s, ×100 oil).'''
<br />
<FlashCard questions="2">
|q1=What is the most likely diagnosis?
|a1=
The clinical signs, signalment and cytological observations are most consistent with perianal adenoma. <br><br>
This tumour is most common in older, sexually intact dogs (>8 years of age). Multiple tumours in the area around the anus are common, as are bleeding and ulcerative lesions. <br><br>
These tumours are rarely malignant in males.
|l1=Adenoma#Tumours of the Perianal Area
|q2=What therapy would you recommend?
|a2=
*Surgical excision is recommended.
*Castration will arrest tumour growth and should be done at the same time, as this tumour is testosterone dependent.
*Oestrogen therapy is recommended in cases in which the tumour cannot be completely removed, and it may also be used following surgery as adjunct therapy.
*Antibiotic therapy may be needed if concomitant infection is suspected.<br><br>
Note: The cytological features of perianal adenoma are classic in this case.
*The cells are typically large and resemble hepatocytes and are referred to as ‘hepatoid’.
*They typically have round, central nuclei with single, distinct nucleoli and moderate to abundant, oval to angular cytoplasm.
*They usually occur in cohesive groups.
*In some cases, small ‘reserve’ cells also may be apparent mixed with the larger hepatoid cells.
*There may be concurrent inflammation and/or haemorrhage. <br><br>
Perianal adenocarcinoma is less common and exhibits more bizarre and/or variable features compatible with malignancy. It may present as a relatively undifferentiated malignancy cytologically and require surgical biopsy and histological evaluation to confirm cell type of origin.
|l2=Adenoma#Tumours of the Perianal Area
</FlashCard>
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[[Category:Cytology Q&A]]
[[Image:|centre|500px]]
<br />
'''A ten-year-old entire male Beagle presents with multiple nodular enlargements surrounding the anus. This is associated with ulceration and bleeding and is accompanied by a disagreeable odour. Fine needle aspiration is performed and smears prepared (Wright’s, ×100 oil).'''
<br />
<FlashCard questions="2">
|q1=What is the most likely diagnosis?
|a1=
The clinical signs, signalment and cytological observations are most consistent with perianal adenoma. <br><br>
This tumour is most common in older, sexually intact dogs (>8 years of age). Multiple tumours in the area around the anus are common, as are bleeding and ulcerative lesions. <br><br>
These tumours are rarely malignant in males.
|l1=Adenoma#Tumours of the Perianal Area
|q2=What therapy would you recommend?
|a2=
*Surgical excision is recommended.
*Castration will arrest tumour growth and should be done at the same time, as this tumour is testosterone dependent.
*Oestrogen therapy is recommended in cases in which the tumour cannot be completely removed, and it may also be used following surgery as adjunct therapy.
*Antibiotic therapy may be needed if concomitant infection is suspected.<br><br>
Note: The cytological features of perianal adenoma are classic in this case.
*The cells are typically large and resemble hepatocytes and are referred to as ‘hepatoid’.
*They typically have round, central nuclei with single, distinct nucleoli and moderate to abundant, oval to angular cytoplasm.
*They usually occur in cohesive groups.
*In some cases, small ‘reserve’ cells also may be apparent mixed with the larger hepatoid cells.
*There may be concurrent inflammation and/or haemorrhage. <br><br>
Perianal adenocarcinoma is less common and exhibits more bizarre and/or variable features compatible with malignancy. It may present as a relatively undifferentiated malignancy cytologically and require surgical biopsy and histological evaluation to confirm cell type of origin.
|l2=Adenoma#Tumours of the Perianal Area
</FlashCard>
{{#tag:imagemap|Image:Next Question.png{{!}}center{{!}}200px
rect 0 0 860 850 [[Cytology Q&A 08|Cytology Q&A 08]]
desc none}}
[[Category:Cytology Q&A]]