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Created page with "{{Template:Manson}} [[Image:|centre|500px]] <br /> '''A seven-year-old neutered male Jack Russell Terrier presented with an interdigital mass of several weeks’ duration. Sm..."
{{Template:Manson}}
[[Image:|centre|500px]]
<br />
'''A seven-year-old neutered male Jack Russell Terrier presented with an interdigital mass of several weeks’ duration. Smears were made from an aspirate of the mass.'''
<br />
<FlashCard questions="3">
|q1=What features are illustrated in these photomicrographs (both Wright–Giemsa, ×50 oil)?
|a1=
*There are a few erythrocytes and moderate to high nucleated cellularity.
*The nucleated cells include many neutrophils, a moderate number of foamy, active macrophages and a few spindle cells.
*The spindle cells have granular, evenly distributed chromatin and the nuclei contain one to several small but distinct nucleoli.
*The cytoplasm is wispy and often has bipolar extensions.
|l1=
|q2=What is your interpretation of these findings?
|a2=
The cytological features are consistent with moderate to marked pyogranulomatous inflammation with spindle cell proliferation, most likely fibroplasia.
|l2=
|q3=What comments do you have regarding these findings?
|a3=
*The cytological finding of pyogranulomatous inflammation may be nonspecific, but the possibility of a reaction to a foreign body or penetrating wound of the interdigital area should be considered.
*This type of inflammation may or may not be easily resolved.
*The spindle cells are consistent with a proliferative population, most likely a fibroplastic response.<br><br>
Atypical spindle cells with nucleoli and increased numbers typical of proliferation represent a diagnostic problem for all cytologists. <br><br>
When present in small numbers and accompanied by the type of inflammation found in this specimen, they are most likely due to fibroplasia. <br><br>
However, in some cases, spindle cell proliferations may be difficult to differentiate and it may be difficult or impossible to separate fibroplasia from an actively growing benign tumour or a malignant one. <br><br>
Cellularity, degree of atypia and other concurrent features all have to be considered. In some cases, cytological evaluation can help separate these conditions with a high degree of confidence.<br><br>
In others the differential diagnoses cannot be differentiated on the basis of cytology alone and a biopsy will be needed to determine the definitive diagnosis.
|l3=
</FlashCard>
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[[Category:Cytology Q&A]]
[[Image:|centre|500px]]
<br />
'''A seven-year-old neutered male Jack Russell Terrier presented with an interdigital mass of several weeks’ duration. Smears were made from an aspirate of the mass.'''
<br />
<FlashCard questions="3">
|q1=What features are illustrated in these photomicrographs (both Wright–Giemsa, ×50 oil)?
|a1=
*There are a few erythrocytes and moderate to high nucleated cellularity.
*The nucleated cells include many neutrophils, a moderate number of foamy, active macrophages and a few spindle cells.
*The spindle cells have granular, evenly distributed chromatin and the nuclei contain one to several small but distinct nucleoli.
*The cytoplasm is wispy and often has bipolar extensions.
|l1=
|q2=What is your interpretation of these findings?
|a2=
The cytological features are consistent with moderate to marked pyogranulomatous inflammation with spindle cell proliferation, most likely fibroplasia.
|l2=
|q3=What comments do you have regarding these findings?
|a3=
*The cytological finding of pyogranulomatous inflammation may be nonspecific, but the possibility of a reaction to a foreign body or penetrating wound of the interdigital area should be considered.
*This type of inflammation may or may not be easily resolved.
*The spindle cells are consistent with a proliferative population, most likely a fibroplastic response.<br><br>
Atypical spindle cells with nucleoli and increased numbers typical of proliferation represent a diagnostic problem for all cytologists. <br><br>
When present in small numbers and accompanied by the type of inflammation found in this specimen, they are most likely due to fibroplasia. <br><br>
However, in some cases, spindle cell proliferations may be difficult to differentiate and it may be difficult or impossible to separate fibroplasia from an actively growing benign tumour or a malignant one. <br><br>
Cellularity, degree of atypia and other concurrent features all have to be considered. In some cases, cytological evaluation can help separate these conditions with a high degree of confidence.<br><br>
In others the differential diagnoses cannot be differentiated on the basis of cytology alone and a biopsy will be needed to determine the definitive diagnosis.
|l3=
</FlashCard>
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rect 0 0 860 850 [[Cytology Q&A 18|Cytology Q&A 18]]
desc none}}
[[Category:Cytology Q&A]]