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→Bovine Respiratory Syncytial Virus (BRSV)
===Bovine Respiratory Syncytial Virus (BRSV)===
===Bovine Respiratory Syncytial Virus (BRSV)===
*More serious than [[Paramyxoviridae#Parainfluenza -3 (PI-3)|PI-3]]
*'''Pathogenesis''':
*Replicates in basal epithelium -> throughout upper respiratory tract -> bronchial tree
**More serious than [[Paramyxoviridae#Parainfluenza -3 (PI-3)|PI-3]]
*Syncytia form -> shed into bronchioles
**Causes [Viral infections#Respiratory syncytial virus|respiratory infection]]
*Complications include [[Lungs - ventilation#Emphysema|emphysema]] and [[Lungs - circulatory#Pulmonary oedema|oedema]], drop in milk yield in adult cattle
**Replicates in nasal epithelium -> throughout upper respiratory tract -> bronchial tree
*Bovine respiratory syncytial virus in [[Viral infections#Respiratory syncytial virus|respiratory infection]]
**Syncytia form -> shed into bronchioles
*Diagnosis is same as for [[Paramyxoviridae#Parainfluenza -3 (PI-3)|PI-3]]
**Complications include [[Lungs - ventilation#Emphysema|emphysema]] and [[Lungs - circulatory#Pulmonary oedema|oedema]], drop in milk yield in adult cattle
*'''Epidemiology''':
**Subclinical reinfections are important in spreading disease
**More than 70% of cattle in the UK have antibodies to BRSV
*'''Diagnosis''' is same as for [[Paramyxoviridae#Parainfluenza -3 (PI-3)|PI-3]]
*'''Control'''
**Improve husbansry as in [[Paramyxoviridae#Parainfluenza -3 (PI-3)|PI-3]]
**Vaccines are available but not effective as need to stimulate cytotoxic T-cells
*<small>'''Reference''': Bryson, 1999, Update on calf pneumonia, CPD Veterinary Medicine, 1,3, 90-95</small>