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Degenerative Joint Disease (view source)
Revision as of 14:47, 7 September 2011
, 14:47, 7 September 2011no edit summary
[[Image:DJD horse.jpg|right|thumb|200px|<small><center>DJD in a horse (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
[[Image:DJD horse.jpg|right|thumb|200px|<small><center>DJD in a horse (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
Degenerative joint disease is the '''progressive deterioration of articular cartilage''' and is characterised by hyaline cartilage thinning, joint effusion and periarticular osteophyte formation.
Degenerative joint disease is the '''progressive deterioration of articular cartilage''' and is characterised by hyaline cartilage thinning, joint effusion and periarticular osteophyte formation.
'''Osteophytes''' form at the junction between synovium and bone. Joint inflammation leads to the release of factors which drive cells to multiply and differentiate into chondroblasts and osteoblasts. There is '''matrix deposition, mineralisation and growth''' of the osteophyte. Mineralised osteophytes develop a trabecular structure and retain a cartilage surface, and when mature may become incorporated into the metaphysis itself.
'''Chondrocyte necrosis''' is initiated, degradative enzymes are released and '''synovitis''', continued cartilage degradation and '''inflammation''' occur. There is loss of proteoglycans and lubrication in the joint.
'''Chondrocyte necrosis''' is initiated, degradative enzymes are released and '''synovitis''', continued cartilage degradation and '''inflammation''' occur. There is loss of proteoglycans and lubrication in the joint.
[[Equine Orthopaedics and Rheumatology Q&A 13]]
[[Equine Orthopaedics and Rheumatology Q&A 13]]
[[Small Animal Orthopaedics Q&A 01]]
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Corr, S. (2009) '''Locomotor module: osteoarthritis''' ''RVC student notes''
Corr, S. (2009) '''Locomotor module: osteoarthritis''' ''RVC student notes''
Lewis, D. (1998) '''Small Animal Orthopaedics: self-assessment colour review''' ''Manson Publishing''