282 bytes added ,  13:32, 16 September 2011
no edit summary
Line 1: Line 1:  
== Introduction ==
 
== Introduction ==
Hepatocytic necrosis can occur following severe metabolic disturbances, toxic substances, nutritional deficiencies and through the action of micro-organisms.
+
Hepatocytes are the epithelial cells of the liver, and these are the main targets of most liver diseases. They can ultimately undergo necrosis, a form of cell death, after lethal injury. This can occur following severe metabolic disturbances, toxic insults, nutritional deficiencies and through the action of micro-organisms.
 
<br>
 
<br>
[[Liver - Anatomy & Physiology|Liver]] cell necrosis has been classified on an anatomic basis with reference to the distribution of the lesion.
+
Despite many types of injury that the liver is subjected to, the resultant necrosis occurs in one of three patterns:
   −
== Random Foci (Focal)==
+
== Random Necrosis (Focal)==
Microscopic foci of necrosis are not related to any particular part of the liver lobule and can be due to a variety of insults such as, systemic viral, bacterial and parasitic infections and as a result of bacteria being absorbed from the gut.
+
In this form of necrosis, there is no distinct pattern of lesions - small foci of necrosis are randomly scattered throughout the liver, and may be either microscopic or just visible to the naked eye. They can result from a variety of insults such as - systemic viral, bacterial and parasitic infections, or as a result of bacteria being absorbed from the gut.
 
<br>
 
<br>
Examples include  
+
Examples of conditions that result in random focal hepatic necrosis include:
*[[Equine Herpesvirus 1|Equine herpes virus]] infection; necrosis found in aborted foetuses.
+
*[[Equine Herpesvirus 1|Equine herpes virus 1]] infection found in aborted foetuses
*[[Salmonellosis]]; necrosis found in the liver of calves due to the ''S. dublin'' serotype.
+
*Septicaemia in association with [[Salmonellosis|salmonellosis]], tularaemia and [[Listeriosis|listeriosis]]
*[[Toxoplasmosis - Cat and Dog|Toxoplasmosis]] (miliary necrosis), which is found in affected dogs and cats.
+
*[[Toxoplasmosis - Cat and Dog|Toxoplasmosis]] in dogs and cats
     
Author, Donkey, Bureaucrats, Administrators
53,803

edits