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Actinobacillus species (view source)
Revision as of 12:54, 20 December 2007
, 12:54, 20 December 2007no edit summary
*Lung scarring and pleural adhesions in many recovered animals
*Lung scarring and pleural adhesions in many recovered animals
*Solid immunity develops in recovered animals to all serotypes
*Solid immunity develops in recovered animals to all serotypes
*The disease is spread between herds by carrier pigs
*The bacteria on the palatine tonsil are undetected by serologucal tests and swabbing, and can therefore cause an outbreak in naive pigs
*Killed and bacterin vaccines are available
*Produce one or two RTX group cytolytic toxins
*RTX toxins:
**'Repeat in ToXin' - named because there are several peptide repeats within the molecules
**Produced by various Gram-negative bacteria, including
**Possess four contiguous genes, C, A, B and D
**A is the structural gene; B and D are required for secretion; C is required for post-translational activation of the gene product of A to produce a functional product
**ApxI is a strong haemolysin with cytolytic activity
**ApxII is a weak haemolysin
**ApxIII is a cytotoxin
**Different ''Actinobacillus pleuropneumonia'' serotypes secrete a particular combination of toxins; American serotypes secrete ApxI and II; European serotypes secrete ApxII and III