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*RTX toxins:
 
*RTX toxins:
 
**'Repeat in ToXin' - named because there are several peptide repeats within the molecules
 
**'Repeat in ToXin' - named because there are several peptide repeats within the molecules
**Produced by various Gram-negative bacteria, including [[Escherichia coli|''E. coli'']], [[Bordetella|''Bordetella sp.'']] and [[''Pasteurella haemolytica#Pasterurella''|''Pasteurella haemolytica'']]
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**Produced by various Gram-negative bacteria
**Possess four contiguous genes, C, A, B and D
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**Possess four contiguous genes, A, B, C and D
**A is the structural gene; B and D are required for secretion; C is required for post-translational activation of the gene product of A to produce a functional product
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**A is the structural gene; B and D are required for secretion; C allows post-translational activation of the gene product of A into a functional product
 
**ApxI is a strong haemolysin with cytolytic activity
 
**ApxI is a strong haemolysin with cytolytic activity
 
**ApxII is a weak haemolysin  
 
**ApxII is a weak haemolysin  
 
**ApxIII is a cytotoxin
 
**ApxIII is a cytotoxin
 
**Different ''Actinobacillus pleuropneumonia'' serotypes secrete a particular combination of toxins; American serotypes secrete ApxI and II; European serotypes secrete ApxII and III
 
**Different ''Actinobacillus pleuropneumonia'' serotypes secrete a particular combination of toxins; American serotypes secrete ApxI and II; European serotypes secrete ApxII and III
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