Changes

==Introduction==

==Introduction==

Sertoli cells are those which act as ''nurse cells'' to the developing spermatozoa. The sertoli cells engulf the spermatozoa, are structurally important in the seminiferous tubules and form the blood-testis barrier.

[[Testes and Epididymis - Anatomy & Physiology|Sertoli cells]] are those which act as ''nurse cells'' to the [[Spermatogenesis and Spermiation - Anatomy & Physiology|developing spermatozoa]]. The sertoli cells engulf the spermatozoa, are structurally important in the seminiferous tubules and form the blood-testis barrier.

Sertoli cell tumours are more common and appear earlier in '''retained abdominal or inguinal testes''' than in scrotal testes.

Sertoli cell tumours are more common and appear earlier in '''retained abdominal or inguinal testes''' than in scrotal testes.

:prostate enlargement and squamous metaplasia

:prostate enlargement and squamous metaplasia

'''Skin changes''' might include: bilateral symmetrical non pruritic alopecia, hyperpigmentation, seborrhea and otitis externa.

'''Skin changes''' might include: bilateral symmetrical non pruritic alopecia, hyperpigmentation, [[seborrhea]] and [[Otitis Externa - Cat and Dog|otitis externa]].

If '''bone marrow suppression''' occurs, systemic signs such as dullness, anaemia and thrombocytopaenia will be present.

If '''bone marrow suppression''' occurs, systemic signs such as dullness, [[anaemia]] and [[thrombocytopaenia]] will be present.

==Diagnosis==

==Diagnosis==

'''Physical examination''' may reveal a mass or there may be cryptorchidism.

'''Physical examination''' may reveal a mass or there may be [[cryptorchidism]].

'''Haematology and biochemistry''' will help identify bone marrow suppression.

'''Haematology and biochemistry''' will help identify bone marrow suppression.

==Treatment==

==Treatment==

Treatment involves '''castration'''. Alopecia and feminisation should resolve within '''2-6 weeks''' unless functional metastases or extratesticular tumours are present.

Treatment involves '''castration'''. [[Alopecia]] and feminisation should resolve within '''2-6 weeks''' unless functional metastases or extratesticular tumours are present.

If metastasis occurs '''chemotherapy''' is a possible treatment option.

If metastasis occurs '''chemotherapy''' is a possible treatment option.

Harvey, R. (2009) '''A colour handbook of skin diseases of the dogs and cat''' ''Manson Publishing''

Harvey, R. (2009) '''A colour handbook of skin diseases of the dogs and cat''' ''Manson Publishing''

 

[[Category:To Do - Reproductive]]

[[Category:Reproductive Diseases - Dog]]

[[Category:Reproductive Diseases - Cat]]

[[Category:Neoplasia]]

[[Category:Neoplasia]]

[[Category:Endocrine System - Pathology]]

[[Category:Endocrine System - Pathology]]

[[Category:Testicles - Pathology]]

[[Category:Testicles - Pathology]]