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The exact aetiology of the syndrome is '''unknown''', but proposed agents include '''parasites, carbon dust, heavy metals, electrical voltage, UV radiation, nutrient deficiencies in vitamin A or C'''. There may not be one particular inciting cause, and the syndrome may simply be a clinical response to various '''stressors'''. These may include overcrowding, poor water quality and poor nutrition.
 
The exact aetiology of the syndrome is '''unknown''', but proposed agents include '''parasites, carbon dust, heavy metals, electrical voltage, UV radiation, nutrient deficiencies in vitamin A or C'''. There may not be one particular inciting cause, and the syndrome may simply be a clinical response to various '''stressors'''. These may include overcrowding, poor water quality and poor nutrition.
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In one study, a '''reovirus''' was isolated from a moribund angelfish with HLLE lesions.  
 
In one study, a '''reovirus''' was isolated from a moribund angelfish with HLLE lesions.  
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A '''grounding device''' can be used to remove stray voltage from the system and changing the activated carbon in the filters may also be helpful.
 
A '''grounding device''' can be used to remove stray voltage from the system and changing the activated carbon in the filters may also be helpful.
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If this is unsuccessful, an infectious cause should be suspected and should be treated with the appropriate antibacterial or antifungal.
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If this is unsuccessful, an infectious cause should be suspected and should be treated with the appropriate antibacterial or antifungal agent.
    
'''0.01% becaplermin''' has been successfully used to treat HLLE in marine tropical fish by applying the product to the debrided skin lesions.
 
'''0.01% becaplermin''' has been successfully used to treat HLLE in marine tropical fish by applying the product to the debrided skin lesions.
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Noga, E. (2010) '''Fish Disease: diagnosis and treatment''' ''Wiley-Blackwell''
 
Noga, E. (2010) '''Fish Disease: diagnosis and treatment''' ''Wiley-Blackwell''
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[[Category:To Do - Helen]]
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[[Category:To Do - Review]]
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{{review}}
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[[Category:Fish Diseases]]
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[[Category:Expert Review - Exotics]]
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