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Pharmacokinetics
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Revision as of 23:32, 9 May 2012
96 bytes added
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23:32, 9 May 2012
→Properties of the Drug
Line 31:
Line 31:
===Properties of the Drug===
===Properties of the Drug===
−
* Lipid solubility - the more lipid soluble a drug the
easier
it is absorbed across the bilayer
+
* Lipid solubility - the more lipid soluble a drug the
more readily
it is absorbed across the bilayer
−
* Chemical nature - ie. Is it basic or acidic? Is it
ionised
or not?
+
* Chemical nature - ie. Is it basic or acidic? Is it
ionized
or not?
−
* Molecular weight
+
* Molecular weight
- lower molecular weight compounds are more readily absorbed than large M.W. compounds.
−
* Stability in the
gastro-intestinal
tract - only applies to orally administered drugs
+
* Stability in the
gastrointestinal
tract-
this
only applies to orally administered drugs
===Physiological Variables===
===Physiological Variables===
Natashavilchez
2
edits