The corneal '''endothelium''' produces Descemet’s membrane throughout life, but its own powers of replication diminish in early life. When endothelial cells die, they are replaced by neighbouring cells spreading to fill the gap. Consequently, the endothelium thins and descemet’s membrane thickens with age. The endothelium is a single layer of cells of high metabolic activity and are crucial in maintaining dehydration of the cornea and thus corneal clarity. The endothelial cells actively pump fluid that can accumulate, from tear film etc, out of the cornea. | The corneal '''endothelium''' produces Descemet’s membrane throughout life, but its own powers of replication diminish in early life. When endothelial cells die, they are replaced by neighbouring cells spreading to fill the gap. Consequently, the endothelium thins and descemet’s membrane thickens with age. The endothelium is a single layer of cells of high metabolic activity and are crucial in maintaining dehydration of the cornea and thus corneal clarity. The endothelial cells actively pump fluid that can accumulate, from tear film etc, out of the cornea. |