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Hypertrophic Cardiomyopathy - Feline Cardiomyopathies (view source)
Revision as of 11:49, 3 December 2012
, 11:49, 3 December 2012no edit summary
===Genetic Testing===
===Genetic Testing===
A causative mutation for HCM has been identified in Maine Coon and Ragdoll cats. This mutation involves the sarcomeric gene for cardiac myosin binding protein C (MYBPC3) in both breeds. However, the mutation in the two breeds appears in different regions of this gene. In Maine Coons it is between domains C0 and C1, in Ragdolls it is in domain 6. There are likely additional mutations that are yet to be identified in Maine Coon cats, as some cats with phenotypic evidence of HCM do not have an identifyable mutation in the MYBPC gene. Conversely, cats may carry the mutation without having phenotypic evidence of HCM.
A causative mutation for HCM has been identified in Maine Coon and Ragdoll cats. This mutation involves the sarcomeric gene for cardiac myosin binding protein C (MYBPC3) in both breeds. However, the mutation in the two breeds appears in different regions of this gene. In Maine Coons it is between domains C0 and C1, in Ragdolls it is in domain 6. There are likely additional mutations that are yet to be identified in Maine Coon cats, as some cats with phenotypic evidence of HCM do not have an identifyable mutation in the MYBPC gene. Conversely, cats may carry the mutation without having phenotypic evidence of HCM.
==Differential Diagnoses==
Before a diagnosis of HCM can be made, causes of secondary myocardial hypertrophy need to be excluded. These include:
* Systemic hypertension
* Hyperthyroidism
* Hypovolaemia (pseudohypertrophy)
* Methylprednisolone acetate administration
* Infiltrative myocardial neoplasia e.g. Lymphoma
* Feline muscular dystrophy
==Treatment==
==Treatment==
==Prognosis==
==Prognosis==