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* In cattle it has been known that high doses result in fatty infiltration of the liver. This hepatotoxic nature of the drug means that they shouldn't be used if hepatic impairment is suspected.
 
* In cattle it has been known that high doses result in fatty infiltration of the liver. This hepatotoxic nature of the drug means that they shouldn't be used if hepatic impairment is suspected.
 
* Oxytetracycline is irritant to tissues, especially in long-acting forms and shouldn't be used in small animals and horses.
 
* Oxytetracycline is irritant to tissues, especially in long-acting forms and shouldn't be used in small animals and horses.
* Doxycycline can cause oesophagitis and should be avoided if an animal id dysphagic or is vomiting.
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* Doxycycline can cause oesophagitis and should be avoided if an animal is dysphagic or is vomiting.
 
* In man phototoxicity is a reported side-effect.
 
* In man phototoxicity is a reported side-effect.