Changes

The cervix retains the foetus in the uterus.

The cervix retains the foetus in the uterus. Connective tissue resists stretch, allowing distension of the uterine body whilst maintaining the cervix in a closed state.  For the foetus to move out of the uterus, the cervix must soften or 'ripen'.

 

The cervix is composed of:  

The cervix is composed of:  

* Collagen fibre bundles

* Collagen fibre bundles: helical strands of amino acids bound together to form fibrils

* Proteoglycan Matrix: protein core with glycosaminoglycan branches

* Proteoglycan Matrix: protein core with glycosaminoglycan branches (GAGs).  GAGs determine the degree of collagen fibre aggregation.  An increased GAG content reduces collagen aggregation and vice versa.

Connective tissue resists stretch, allowing distension of the uterine body whilst maintaining the cervix in a closed state.

Cervical softening involves two changes in the intracellular matrix: